Within this context, there have been tremendous efforts to advance fabrication technology surpassing vesicle fusion, which has led to the development of next-generation SLB platforms and opened the door to a wide range of new applications such as diagnostic biosensors, biocompatible coatings, and bioanalytical tools. However, this technique is highly dependent on the vesicle preparation, lipid compositions, and types of surface materials. To date, the most favored approach to form SLBs is vesicle fusion, which involves vesicle adsorption and simultaneous rupture on a solid surface. Moreover, the functionalization of SLBs by modulating the lipid compositions and/or incorporating biomolecules provides versatile opportunities to improve understanding of membrane properties and molecular interaction as well as the applications to analytic platforms and diagnostic biosensing. Their compatibility with a variety of surface-sensitive biophysical techniques highlights the importance of designing and constructing SLBs on target materials. ![]() ![]() Supported lipid bilayers (SLBs) are artificial cell membrane platforms that recapitulate key aspects of lipid membrane architecture on material surfaces.
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